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Primary squamous cell carcinoma of the larynx

โœ Scribed by F. R. Hendrickson; T. C. Kline Jr.; G. G. Hibes


Book ID
115040003
Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
890 KB
Volume
85
Category
Article
ISSN
0023-852X

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The mutational inactivation of suppressor genes, a process required for cancer progression, generates new genetic subclones within a tumor. The allelic losses that frequently unmask these mutations serve not only as markers of the chromosomal locations of these genes but also as clonal fingerprints