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Primary pulmonary rhabdomyosarcoma in childhood: Clinico-biologic features in two cases with review of the literature

โœ Scribed by Schiavetti, Amalia; Dominici, Carlo; Matrunola, Marco; Capocaccia, Paolo; Ceccamea, Alberto; Castello, Manuel A.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
567 KB
Volume
26
Category
Article
ISSN
0098-1532

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โœฆ Synopsis

The cases of two children under three years of age with primary pulmonary rhabdomyosarcoma and no associated lung malformations are reported and a review of the literature is presented. In both, complete surgical removal of the tumor was performed and histologic examination revealed embryonal subtype. Flow cytometric assessment showed a tumor-cell diploid DNA con-tent. Postoperative radio-and chemotherapy were carried out, but in spite of treatment both girls died because of disease progression, fourteen and nine months after diagnosis. The importance of associated cystic lung malformations and DNA content in predicting clinical outcome of primary pulmonary rhabdomyosarcoma is evaluated.

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