Primary prevention of neural-tube defects and some other congenital abnormalities by folic acid and multivitamins: history, missed opportunity and tasks

Periconceptional folic acid and multivit

Periconceptional folic acid and multivitamin supplementation for the prevention of neural tube defects and other congenital abnormalities

✍ Andrew E. Czeizel 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB 👁 3 views

## Abstract The pioneering studies of Smithells et al. showed the reduction of recurrent neural‐tube defects (NTD) after periconceptional folic acid‐containing multivitamin supplementation. The Hungarian Periconceptional Service was established in 1984, and this primary health care system offered a