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Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young

✍ Scribed by VELHO, G


Book ID
123210286
Publisher
The Lancet
Year
1992
Tongue
English
Weight
701 KB
Volume
340
Category
Article
ISSN
0140-6736

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The maturity-onset diabetes of the young (MODY), an autosomal dominant form of non-insulin dependent diabetes mellitus (NIDDM), is caused by mutations in the glucokinase (GK, MODY 2) and in the hepatocyte nuclear factor 1 (MODY 3) and 4 (MODY1) genes. We have screened the glucokinase gene by the pol