Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young
β Scribed by VELHO, G
- Book ID
- 123210286
- Publisher
- The Lancet
- Year
- 1992
- Tongue
- English
- Weight
- 701 KB
- Volume
- 340
- Category
- Article
- ISSN
- 0140-6736
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π SIMILAR VOLUMES
Glucokinase is a key regulatory enzyme in the pancreatic beta-cell. It plays a crucial role in the regulation of insulin secretion and has been termed the glucose sensor in pancreatic beta-cells. Given its central role in the regulation of insulin release it is understandable that mutations in the g
The maturity-onset diabetes of the young (MODY), an autosomal dominant form of non-insulin dependent diabetes mellitus (NIDDM), is caused by mutations in the glucokinase (GK, MODY 2) and in the hepatocyte nuclear factor 1 (MODY 3) and 4 (MODY1) genes. We have screened the glucokinase gene by the pol