Primary mediastinal germ cell tumor with intratubular germ cell neoplasia of the testis--further support for germ cell origin of these tumors : A case report

✍ Scribed by K. C. Lee

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 44 KB
• Volume: 80
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19970901)80:5<1007::aid-cncr36>3.0.co;2-c

✦ Synopsis

have seen three more patients with both RCC and the tumor of the left testis. The specific type of subsequent cancer may depend partly on alterations NHL. Two of these three patients had metachronous tumors; however, one patient who underwent ne-in the microenvironment that is ''bathing'' the stem cell in question. 6 In fact, changes in the cellular phrectomy for a renal mass had both RCC and NHL diagnosed at surgery in the same kidney. milieu caused by irradiation 6 and/or chemotherapeutic agents 3 may explain the occurrence of treat-The fact that we continue to see these malignancies at our institution supports the hypothesis that this ment-related cancers in general. It is important, however, to point out that despite advances in mo-coincidental finding is too frequent to be explained by chance alone. That other institutions are seeing similar lecular genetics, we are not quite able to delineate, clearly, the clonality of cells within a single tu-patients would suggest that the observation is not solely based on a referral bias. We agree that further mor, 7,8 let alone track genetic changes that can occur during the progression, including metastasis 9,10 investigation into both chromosomal mutation and cytokine production is warranted, and we are actively and recurrence, 11 of a given tumor; and we are even less prepared to track such changes in different tu-pursuing these possibilities.

mors arising in the same patient.