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Primary Human Splenic Macrophages, but Not T or B Cells, Are the Principal Target Cells for Dengue Virus Infection In Vitro

โœ Scribed by Blackley, S.; Kou, Z.; Chen, H.; Quinn, M.; Rose, R. C.; Schlesinger, J. J.; Coppage, M.; Jin, X.


Book ID
121704671
Publisher
American Society for Microbiology
Year
2007
Tongue
English
Weight
566 KB
Volume
81
Category
Article
ISSN
0022-538X

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## Abstract A better understanding of the pathogenesis of dengue hemorrhagic fever and dengue shock syndrome requires the precise identification of dengue virus (DV) permissive target cells. To examine the relative DV permissiveness among cell subsets, we inoculated unfractionated human peripheral