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Primary exploration of CDR3 spectratyping and molecular features of TCR β chain in the peripheral blood and tissue of patients with colorectal carcinoma

✍ Scribed by Jianwei Zhou; Rui Ma; Rong Luo; Yongping Sun; Xiaoyan He; Wanbang Sun; Wentai Tang; Xinsheng Yao


Book ID
108078835
Publisher
Elsevier
Year
2010
Tongue
English
Weight
741 KB
Volume
34
Category
Article
ISSN
1877-7821

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✍ Heidi Schwarzenbach; Eray Goekkurt; Klaus Pantel; Daniela E. Aust; Jan Stoehlmac 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 325 KB

## Abstract As a key enzyme in folate metabolism, the thymidylate synthase (TS) is important for the synthesis of nucleotides. Its polymorphisms may affect the TS gene expression and the susceptibility for Fluoropyrimidine (FU)‐based chemotherapies. In this study, we assessed the relationship betwe