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Primary common bile duct anastomosis in the rat using microsurgical techniques

✍ Scribed by Chuphan Chansmorn; Dr. William C. Lineaweaver; Heidi Tonken; Feng Zhang; Dante Campagna-Pinto; Leonard Newlin; Kenneth Yim; Harry J. Buncke

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
814 KB
Volume
15
Category
Article
ISSN
0738-1085

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✦ Synopsis

Abstract

In a rat model, we attempted to describe the natural healing course of the common bile duct (CBD) after primary microsurgical repair. Fifty‐three rats were divided into experimental groups with CBD microsurgical anastomoses and control groups with CBD mobilization and ligation. Examination of three experimental groups at 1 week, 1 month, and 3 months showed evolving inflammation and stricture changes with eventual patent, healed ducts in 92% of animals at the end of 3 months following transection and repair. There were no histologic abnormalities in the livers. There were fibrotic ducts and hepatic stasis and cirrhosis changes in the control group with CBD ligation. This study demonstrates that microsurgical techniques can achieve successful primary biliary repair in the rat. Β© 1994 Wiley‐Liss, Inc.

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