Primary chemotherapy followed by radiotherapy for localized non-hodgkin's lymphomas: A preliminary report

✍ Scribed by Sampi, Kazumi ;Takeoda, Syozi ;Hattori, Masao

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 458 KB
• Volume: 11
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950110409

✦ Synopsis

Abstract

Twenty‐eight evaluable patients with clinical stage I‐II of non‐Hodgkin's lymphoma were treated with primary chemotherapy followed by involved field radiotherapy. The frequency of the follicular versus diffuse histological pattern was 14.3 versus 85.7%, and 24/28 (86%) of patients were in stage II. No lymphoma examined was identified as T‐cell in origin. A complete response was obtained in 21 (78%) of 27 patients with measurable disorder. [Gastrectomy rendered one patient disease‐free survival, and one partially responded showing a complete reponse after radiotherapy.] Sixteen (76%) of the 21 employed for complete response. After 36 months, elapsed disease‐free survival was rated at 100% together with actuarial survival of all patients at 81%. Chemotherapy contributed to reduce the radiation dosage to 3000 rads and to control the areas infiltrated with preexisting tumors. These findings, although the median follow‐up time in our study remains short (28 months), provide a strong rationale for further clinical trials of primary chemotherapy, followed by regional radiotherapy for localized stages of non‐Hodgkin's lymphomas.