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Primary central nervous system Burkitt's lymphoma presenting as Guillain-Barré syndrome

✍ Scribed by Toren, A. ;Mandel, M. ;Shahar, E. ;Rimmoni, E. ;Roizin, H. ;Neuman, Y. ;Brok-Simoni, F. ;Mark, Z. ;Biniaminov, M. ;Rosenthal, E. ;Segal, M. ;Frand, M. ;Ben-Bassat, I. ;Rechavi, G.

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
690 KB
Volume
23
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

A rare case of CNS Burkitt's lymphoma presenting as acute Guillain‐Barré syndrome is presented. A 6‐year‐old previously healthy female presented with acute onset of limb and truncal weakness, involvement of ocular and bulbar nerves, and areflexia. The clinical diagnosis of Guillain‐Barré syndrome prompted treatment with intravenous gammaglobulin with no response. A lumbar puncture following revealed marked pleocytosis, elevated protein, and decreased glucose. Immunological, cytological, and molecular studies of these cells confirmed the diagnosis of Burkitt's lymphoma IgM, kappa with t(8;14) and rearrangement of the J and kappa immunoglobulin chains. Aggressive systemic and intrathecal chemotherapy were started and within 5 days remission was achieved. The child is in complete remission 2 years from diagnosis. Although very rare, CNS lymphoma should be taken into account in every patient presenting with the clinical features of acute polyneuropathy. © 1994 Wiley‐Liss, Inc.

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