✦ LIBER ✦
Primary and secondary binding sites for lanthanide shift reagents with amides. Differential behavior of cis vs trans amide isomers with LSR
✍ Scribed by Laurine Laplanche Graham
- Book ID
- 102951746
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 526 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0749-1581
No coin nor oath required. For personal study only.
✦ Synopsis
Lanthanide induced shifts (LIS) were measured for four dimethylamides, RCON(CH,),, and four monomethyl amides, RCONHCH,, R = H, CH,, CF, and CCl,, using Eu(fod), in c a and benzene (c6D6) solution. Structural correlations for HCON(CH,), and CH,CON(CH,)2 in both solvents yield a preferred binding site for the Eu(fod), on one of the lone-pair orbitals of the oxygen atom, with a probable site of secondary importance on the other lone-pair orbital. The cis vs trans isomers of HCONHCH, and CH,CONHCH, exhibit remarkably different chemical shift behavior upon addition of Eu(fod),.