Primary amine drug-sensitive poly(vinyl chloride) membrane electrodes based on synthetic macrocyclic polyether derivatives of o-phenanthroline
✍ Scribed by Zeng-Rong Zhang; Ru-Qin Yu
- Book ID
- 102981235
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 660 KB
- Volume
- 285
- Category
- Article
- ISSN
- 0003-2670
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✦ Synopsis
Eight macrocyclic poiyether derivatives of o-phenanthroline were synthesized and used as neutral carriers for preparing polyGiny1 chloride) (PVC) membrane electrodes that sense primary amine species. The potentiometric response characteristics of the electrodes were investigated. The effect of experimental parameters on the electrode performance was studied. The optimum pH range for the benaylamine-sensitive electrode was found to be 6.6-9.0. The membrane composition was optimized by using orthogonal polynomial regression, and the following optimum membrane composition was found: 5.8 mg of PHBN19C7,180 mg of dikooctyl sebacate, 84 mg of PVC and 1.0 mg of potassium tetraphenylborate in a membrane of ca. 5.3 cm*. The electrode sensitive to benzylamine as a model analyte showed a linear response range of 8.0 x 10-6-0.1 mol/l with a detection limit of 8.9 x lo-' mol/l and a slope of 56.5 mV per decade at 25°C. The linear potentiometric response of the mexiletine-sensitive electrode was 4.7 x lo-'-0.1 mol/l and the detection limit was 5.0 x lo-' mol/l with a slope of 59.0 mV per decade at 25°C. These potentiometric response characteristics of the electrodes compared favourabiy with those of electrodes based on dinaphthyl macrocyclic polyethers. The PHENPXTbased electrode was used to determine the mexiletine content in pharmaceutical preparations with satisfactory results.