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Primary AL amyloid polyneuropathy successfully treated with high-dose melphalan followed by autologous stem cell transplantation

✍ Scribed by Nagaaki Katoh; Masayuki Matsuda; Takuhiro Yoshida; Masahide Yazaki; Hiroshi Morita; Kazuo Sakashita; Shu-Ichi Ikeda

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
173 KB
Volume
41
Category
Article
ISSN
0148-639X

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✦ Synopsis

Abstract

We report 2 patients with polyneuropathy associated with amyloid derived from light chains (AL) who were treated successfully with high‐dose melphalan followed by autologous peripheral blood stem cell transplantation (HDM/SCT). Neuropathic symptoms improved in conjunction with normalization of serum‐free light chains. In addition to amyloid deposits in tissues, an amyloidogenic light chain itself produced by abnormal plasma cells might be harmful to peripheral nerve function, and thus HDM/SCT seems to be a promising therapy for primary AL amyloid polyneuropathy. Muscle Nerve, 2010

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