Preweanling sensorial and motor development in laboratory mice: Quantitative trait loci mapping

✍ Scribed by Isabelle Le Roy; Fernando Perez-diaz; Ameziane Cherfouh; Pierre L. Roubertoux

• Book ID: 101265927
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 199 KB
• Volume: 34
• Category: Article
• ISSN: 0012-1630
• DOI: 10.1002/(sici)1098-2302(199903)34:2<139::aid-dev7>3.0.co;2-h

✦ Synopsis

Chromosomal mapping of genes linked with 19 measures of sensorial, motor, and body weight development were investigated. Chromosomal mapping is the first step towards gene identification. When a genomic region is shown to be linked to a trait, it is possible to select a reduced number of candidate genes that have been previously mapped on this region. The involvement of every gene can be individually tested either by molecular (transgenesis, homologous recombination) or traditional methods (congenicity). Mapping was performed using 389 males and females from two inbred strains of laboratory mice C57BL/6By and NZB/ BlNJ, their reciprocal and Thirty-six Quantitative Trait Loci (QTL) were mapped, 12 F s F s.