Preventive effects of insulinlike growth factor-I on steroid-induced muscle atrophy

✍ Scribed by Fumio Kanda; Keiko Takatani; Shiho Okuda; Tatsuo Matsushita; Kazuo Chihara

• Book ID: 101252665
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 176 KB
• Volume: 22
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/(sici)1097-4598(199902)22:2<213::aid-mus9>3.0.co;2-m

✦ Synopsis

We examined the effects of simultaneous administration of recombinant insulinlike growth factor-I (IGF-I) and glucocorticoid on the diameter of muscle fibers in rats. The steroid group received subcutaneous injection of triamcinolone, the IGF-treated group received IGF-I alone, and the steroid plus IGF group received both triamcinolone and IGF-I. After 14 days, each rat was subjected to muscle biopsy of the extensor digitorum longus and soleus. Glucocorticoid treatment caused significant reduction in diameter of muscle fibers, compared to controls. Simultaneous administration of IGF-I significantly attenuated glucocorticoid-induced muscle atrophy. Glucocorticoid increased both urinary concentration of 3-methylhistidine and urinary creatine/creatinine ratio. IGF-I reduced those changes in the urine. We conclude that IGF-I administration prevents, at least partially, the development of steroid myopathy.