Prevention of X-ray-induced late dermal necrosis in the pig by treatment with multi-wavelength light
✍ Scribed by Dr. Mohiaddin Rezvani; Moshe Nissan; John W. Hopewell; Gerard J. M. J. van den Aardweg; Mike E. C. Robbins; Elizabeth M. Whitehouse
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 629 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0196-8092
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✦ Synopsis
Low-level light from a multi-wavelength array of light sources has been used to prevent late X-ray-induced dermal necrosis in the pig. Skin fields, measuring 4 x 4 cm on the flank, were irradiated with a single dose of 23.4 Gy of X-rays. This X-ray dose was associated with the development of a 100% incidence of dermal necrosis, 10-16 weeks after irradiation. These irradiated skin sites were subsequently exposed to light of 660,820,880, and 950 nm wavelengths from a gallium aluminium arsenide multiple wavelength multidiode cluster probe (Biotherapy Medical Laser, 3ML), three times a week, from 4 to 16 weeks or 6 to 16 weeks after X-irradiation. The skin fields were exposed to the light pulsating at either 2.5 Hz or 5 kHz. With light pulsating at 5 kHz, energy densities of 0.22, 0.54, 1.08 2.16, 4.32, and 10.8 J/cm2 were used. Treatment with light pulsating at 2.5 Hz, 6-16 weeks after X-irradiation, or treatment with light pulsating at 5 kHz, 6 1 6 weeks after X-irradiation, did not have a significant effect on the incidence or the latency for the development of ischemic dermal necrosis irrespective of the exposure time to light at each treatment. With light pulsating at 5 kHz, no effect of light dose was observed. However, the overall incidence of dermal necrosis was significantly reduced (P = 0.001) to 52% in the X-irradiated fields receiving treatment with 5 kHz light, 6-16 weeks after X-irradiation. Treatment with light for only three days immediately after X-irradiation with 5 kHz light had no beneficial effect. These findings suggest that light when applied appropriately may be useful in the prevention of late X-ray-induced damage to the dermis provided that it is given for the most appropriate time after X-irradiation. o 1992 Wiley-Liss, Inc.