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Prevention of renal ischemia-reperfusion injury by short hairpin RNA of endothelin A receptor in a rat model

✍ Scribed by Jia, Y.; Zhao, Z.; Xu, M.; Zhao, T.; Qiu, Y.; Ooi, Y.; Yang, B.; Rong, R.; Zhu, T.

Book ID
115502446
Publisher
Royal Society of Medicine Press
Year
2012
Tongue
English
Weight
283 KB
Volume
237
Category
Article
ISSN
1535-3702

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This study investigated the effects of dual endothelin (ET) receptor blockade in rat models of liver ischemia and reperfusion injury (IRI). Three models of IRI were used: (1) in vivo total hepatic warm ischemia with portal shunting for 60 minutes with control (saline) and treatment groups (15 mg/kg