Prevention of platelet adhesion to porous surfaces

✍ Scribed by Predecki, Paul ;Life, L. ;Newman, M. M.

• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 580 KB
• Volume: 14
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.820140407

✦ Synopsis

Abstract

Porous samples of cellulose diacetate/nitrate CAN (millipore filter), polycarbonate PC (nuclepore filter), cellulose diacetate CA, and polydimethyl siloxane SR of various pore sizes were immersed in stirred heparinzied human blood while being perfused with lactated Ringer's solution at variours rates. Control samples were exposed to the blood in the absence of perfusion. The control tests showed that CAN and PC adhered platelets rapidly to plateau levels of 1–5 × 10^6^/cm^2^ in ∼ 4 min, while CA and SR remained platelet‐free. The critical perfusion rate, v to prevent adhesion of platelets (and all formed elements) to the CAN and PC was ∼0.1 cc/min cm^2^ at a shear rate of ∼620 sec^−1^ independent of pore size tested. v increased slightly with stirring rate. A simplified diffusion‐convection model was used to qualitatively account for the effects observed.