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Prevention of irinotecan associated diarrhea by intestinal alkalization. A pilot study in gastrointestinal cancer patients

✍ Scribed by Vicente Valentí Moreno; Joan Brunet Vidal; Hermini Manzano Alemany; Antonia Saulud Salvia; Montserrat Llobera Serentill; Inés Cabezas Montero; Sonia Servitja Tormo; Eugenia Sopena Bert; Josep Gumà Padró


Book ID
107596044
Publisher
Springer Milan
Year
2006
Tongue
Spanish
Weight
398 KB
Volume
8
Category
Article
ISSN
1699-048X

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Prevention of irinotecan (CPT-11)-induce
✍ Yuichiro Takeda; Kunihiko Kobayashi; Yoshiko Akiyama; Tomoyuki Soma; Satoko Hand 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 92 KB

It has been reported that 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11) and its active metabolite, 7-ethyl-10-hydroxy-camptothecin (SN-38), have absorption characteristics of weakly basic drugs, suggesting that alkalization of the intestinal lumen might reduce reabsorpt