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Prevention of endotoxin-induced lethality in mice by calmodulin kinase activator

✍ Scribed by Yasuyuki Asai; Hiroshi Uchida; Hiroyo Yamamoto; Yoshinori Ohyama; Takayoshi Jinno; Yasuhiro Taiji; Kuniyasu Ochiai; Tomohiko Ogawa

Book ID
114304609
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
434 KB
Volume
27
Category
Article
ISSN
0928-8244

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Sepsis and endotoxemia are involved in the development of fulminant hepatic failure, the prognosis of which is extremely poor and the mortality is high, with no available effective therapy. Here, we report that hepatocyte growth factor (HGF) exerts potent antiapoptotic effects in vivo and effectivel