Prevention of diabetes in non-obese diabetic I-Ak transgenic mice
โ Scribed by Slattery, Robyn M.; Kjer-Nielsen, Lars; Allison, Janette; Charlton, Brett; Mandel, Thomas E.; Miller, Jacques F. A. P.
- Book ID
- 118674944
- Publisher
- Nature Publishing Group
- Year
- 1990
- Tongue
- English
- Weight
- 352 KB
- Volume
- 345
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/345724a0
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Diabetes prone NOD female mice were fed diets containing different proteins from just before weaning. Only mice receiving meat meal or casein as the protein source developed diabetes at the rate expected from this colony. Lactalbumin and gluten did not precipitate diabetes except in a small number.
Oral administration of the synthetic immunomodulating drug quinoline-3-carboxamide (Linomide) in the drinking water to 5-week-old female non-obese diabetic (NOD) mice resulted in complete protection from insulitis and maintenance of normal glucose tolerance for over 40 weeks (impaired glucose tolera