Prevention of denervation atrophy in muscle: Mammalian neurotrophic factor is not transferrin

Degeneration of cocultures of spinal mus

Degeneration of cocultures of spinal muscular atrophy muscle cells and rat spinal cord explants is not due to secreted factors and cannot be prevented by neurotrophins

✍ Serge Braun; Bernard Croizat; Marie-Claude Lagrange; Philippe Poindron; Jean-Mar 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 478 KB 👁 2 views

We have shown recently that cocultures of muscle cells from infantile spinal muscular atrophy (SMA) patients innervated by motoneurons of normal rat spinal cord explants undergo a degeneration process, suggesting that muscle may play a role in this atrophy, which previously has been considered to be