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Prevention of congenital abnormalities by periconceptional multivitamin supplementation

✍ Scribed by A.E. Czeizel


Book ID
118892398
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
135 KB
Volume
44
Category
Article
ISSN
0020-7292

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Periconceptional folic acid and multivit
✍ Andrew E. Czeizel 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB 👁 3 views

## Abstract The pioneering studies of Smithells et al. showed the reduction of recurrent neural‐tube defects (NTD) after periconceptional folic acid‐containing multivitamin supplementation. The Hungarian Periconceptional Service was established in 1984, and this primary health care system offered a

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✍ Andrew E. Czeizel; Márta Dobó; Péter Vargha 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 101 KB 👁 1 views

## Abstract ## BACKGROUND The 1984–1991 Hungarian randomized controlled trial (RCT) of periconceptional multivitamin supplementation containing folic acid (0.8 mg) showed a significant reduction in the first occurrence of neural tube defects (NTDs), and of urinary tract and cardiovascular abnormal

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✍ Gong Chen; Xinming Song; Ying Ji; Lei Zhang; Lijun Pei; Jiapeng Chen; Jufen Liu; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 81 KB

## Abstract **BACKGROUND:** Maternal nutritional factors seem to contribute substantially to the complex etiologies of NTDs. Foremost among these factors is the periconceptional use of supplementation containing folic acid, which is associated with a reduction in the risk of women having NTD‐affect

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## Abstract Two previous Hungarian intervention trials showed that periconceptional folic acid‐containing multivitamin supplementation did not change the total (birth + fetal) prevalence of cases with multiple congenital abnormalities (MCAs). However, two US observational studies found an elevated