## Abstract The pioneering studies of Smithells et al. showed the reduction of recurrent neural‐tube defects (NTD) after periconceptional folic acid‐containing multivitamin supplementation. The Hungarian Periconceptional Service was established in 1984, and this primary health care system offered a
Prevention of congenital abnormalities by periconceptional multivitamin supplementation
✍ Scribed by A.E. Czeizel
- Book ID
- 118892398
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 135 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0020-7292
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract ## BACKGROUND The 1984–1991 Hungarian randomized controlled trial (RCT) of periconceptional multivitamin supplementation containing folic acid (0.8 mg) showed a significant reduction in the first occurrence of neural tube defects (NTDs), and of urinary tract and cardiovascular abnormal
## Abstract **BACKGROUND:** Maternal nutritional factors seem to contribute substantially to the complex etiologies of NTDs. Foremost among these factors is the periconceptional use of supplementation containing folic acid, which is associated with a reduction in the risk of women having NTD‐affect
## Abstract Two previous Hungarian intervention trials showed that periconceptional folic acid‐containing multivitamin supplementation did not change the total (birth + fetal) prevalence of cases with multiple congenital abnormalities (MCAs). However, two US observational studies found an elevated