Prevention of bacterial adherence to implant surfaces with a crosslinked albumin coating in vitro
✍ Scribed by Y. H. An; G. W. Stuart; S. J. McDowell; S. E. McDaniel; Q. Kang; R. J. Friedman
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 680 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0736-0266
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✦ Synopsis
Abstract
Titanium surfaces were coated with bovine serum albumin using carbodiimide, a crosslinking agent. The durability of the coated surfaces and the inhibitory effect of the albumin coating on bacterial adherence were tested in vitro for 20 consecutive days at 37°C in phosphate buffered saline, with intermittent agitation. The results showed that only 10% of the coated bovine serum albumin decayed off the surface during the 20‐day incubation period. The inhibition rate of the albumin coating on bacterial adherence remained high (greater than 85% ) throughout the experiment. The results suggested potential use of this crosslinked albumin coating to reduce bacterial adherence and thus the subsequent possibility of prosthetic or implant infection in vivo.