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Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts

✍ Scribed by Mosaad A. Abdel-Wahhab; Hanaa; H. Ahmed; Mohamad M. Hagazi

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 200 KB
Volume: 26
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.1127

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✦ Synopsis

Chemoprevention by extracts of Laurencia obtusa (E1) and Caulerpa prolifera (E2) collected from the Egyptian coast of the Red Sea against aflatoxin B 1 (AFB 1 )-initiated hepatotoxicity in female Sprague-Dawley rats has been studied. Animals were fed aflatoxin-contaminated diet (3 mg kg - ----1 diet) for 6 days then treated orally with pure aflatoxin B 1 (AFB 1 ) (200 µ µ µ µ µg kg - ----1 b.w.) for 4 days either in combination with or before E1 or E2 administration (50 mg kg - ----1 b.w.). AFB 1 resulted in a significant increase in serum alpha fetoprotein, carcinoembryonic antigen, tumor necrosis factor alpha, nitric oxide, interleukin-1α α α α α, procollagen III and lipid peroxidation level in the liver. It caused a significant decrease in food intake, body weight, serum leptin, the activities of glutathione peroxidase, superoxide dismutase and DNA and RNA concentrations in the liver. Cotreatment with AFB 1 and E1 or E2 resulted in an obvious improvement in all tested parameters. Noteworthy, E2 was more effective than E1 in the protection against AFB 1 -induced hepatotoxicity. Copyright

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