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Prevention of acetaminophen-induced liver toxicity by 2(R,S)-n-propylthiazolidine-4(R)-carboxylic acid in mice

✍ Scribed by Chandrika Srinivasan; Walter M Williams; Mukunda B Ray; Theresa S Chen


Book ID
113992531
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
369 KB
Volume
61
Category
Article
ISSN
0006-2952

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The ethylene glycol ether 2-methoxyethanol (ME) and its oxidation product methoxyacetic acid (MAA) are selective embryotoxins and equipotent as inducers of digit malformations when given by gavage to pregnant Cr1:CD-1 ICR BR mice on gestation day 11. Earlier observations showed that the teratogenic