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Prevention by phosphodiesterase inhibitors of antigen-induced contraction of guinea-pig colonic smooth muscle

โœ Scribed by Marilyn Grous; Mary Barnette

Book ID
117960024
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
936 KB
Volume
111
Category
Article
ISSN
0007-1188

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Antigen (ovalbumin)-induced contraction of guinea-pig isolated trachea, which largely resulted from the endogenous release of peptidoleukotrienes, was strongly inhibited by the non-selective phosphodiesterase (PDE) inhibitor theophylline and, more potently, by the selective PDE type IV inhibitors ro