Targeting cyclooxygenase-2 for preventio
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Frank A Sinicrope
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Article
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2006
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John Wiley and Sons
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English
β 262 KB
## Abstract Cyclooxygenaseβ2 (COXβ2) is an inducible enzyme that regulates prostaglandin synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A causal link for COXβ2 in epithelial tumorigenesis was shown in genetically manipulated animal models of colon and bre