Prevention and reversal of lupus in NZB/NZW mice by costimulatory blockade with adeno-associated virus–mediated gene transfer

Long-term reversal of hypercholesterolem

Long-term reversal of hypercholesterolemia in low density lipoprotein receptor (LDLR)-deficient mice by adenovirus-mediated LDLR gene transfer combined with CD154 blockade

✍ Colleen S. Stein; Inês Martins; Beverly L. Davidson 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 354 KB 👁 2 views

## Background: Deficiency of the low density lipoprotein receptor (ldlr) results in abnormal elevation of cholesterol within the intermediate and low density plasma lipoproteins (idl/ldl), and predisposes to early onset atherosclerosis. cholesterol reduction after adenovirus-mediated ldlr gene tran