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Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo

✍ Scribed by Escalante, Aluvia M.; McGrath, Ryan T.; Karolak, Matthew R.; Dorr, Robert T.; Lynch, Ronald M.; Landowski, Terry H.


Book ID
120404872
Publisher
Springer
Year
2013
Tongue
English
Weight
616 KB
Volume
71
Category
Article
ISSN
0344-5704

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## Abstract Cholera toxin irreversibly activates a 43‐kDa guanosine triphosphate (GTP)‐binding protein by adenosine diphosphate ribosylation, resulting in activation of adenylate cyclase and increased intracellular levels of cyclic adenosine monophosphate (cAMP). Because increases in intracellular