Preventing re-replication of chromosomal DNA
โ Scribed by Blow, J. Julian; Dutta, Anindya
- Book ID
- 109958367
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 695 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1471-0072
- DOI
- 10.1038/nrm1663
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A study of sedimentation and buoyant density of Okazaki fragments from mammalian chromosomes along with electron microscopic studies indicate that fragments from about 200 to 1200 nucleotides long may have RNA segments covalently attached. The fragments in some CsCl isopycnic gradients banded in two
Our understanding of the process by which eukaryotes regulate initiation of DNA replication has made remarkable advances in the past few years, thanks in large part to the explosion of genetic and biochemical information on the budding yeast, Saccharomyces cerevisiae. At least three major concepts h
absolutely unfailing way. This problem is largely ignored in traditional studies on eukaryotic DNA replication. ## Summary A hypothesis for the control of eukaryotic DNA replication at the chromosomal level is proposed. The specific regulatory problem arises from the subdivision of the genome int