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Preventing Misfolding of the Prion Protein by Trimethylamine N -Oxide †

✍ Scribed by Bennion, Brian J.; DeMarco, Mari L.; Daggett, Valerie

Book ID
126905961
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
367 KB
Volume
43
Category
Article
ISSN
0006-2960

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✍ Vincenzo Granata; Pasquale Palladino; Barbara Tizzano; Alessandro Negro; Rita Be 📂 Article 📅 2006 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 465 KB 👁 2 views

## Abstract A study of the effect of trimethylamine N‐oxide on the stability of two recombinant forms of the prion protein PrP, an ovine full‐length and a human truncated form, is here reported. Both thermal denaturation and denaturation at room temperature were analyzed at pH values above and belo