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Prevalent breast cancer patients with a homozygous mutant status for CYP2D6*4: response and biomarkers in tamoxifen users

✍ Scribed by A. S. Dieudonné; D. Lambrechts; B. Claes; T. Vandorpe; H. Wildiers; D. Timmerman; J. Billen; K. Leunen; F. Amant; P. Berteloot; A. Smeets; R. Paridaens; C. Weltens; E. Van Limbergen; W. Van den Bogaert; I. Vergote; S. Van Huffel; M. R. Christiaens; P. Neven

Publisher
Springer US
Year
2009
Tongue
English
Weight
224 KB
Volume
118
Category
Article
ISSN
0167-6806

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## Abstract Hypoxia is common in many solid tumours, including breast cancer. Hypoxia triggers the expression of hypoxia inducible factor‐1α (HIF‐1α), and HIF‐1α has been associated with an impaired prognosis in breast cancer and down‐regulation of the oestrogen receptor (ER), potentially affecting