Prevalence of widespreadBRCA1gene mutations in patients with familial breast cancer from St. Petersburg
โ Scribed by N. A. Grudinina; V. I. Golubkov; O. S. Tikhomirova; T. V. Brezhneva; K. P. Hanson; V. B. Vasilyev; M. Yu. Mandelshtam
- Book ID
- 106523083
- Publisher
- SP MAIK Nauka/Interperiodica
- Year
- 2005
- Tongue
- English
- Weight
- 96 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1022-7954
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Family history is a well-recognized risk factor for the development of breast cancer. The isolation of BRCA1 and BRCA2 genes, the two major predisposing genes in familial and to early onset breast and ovarian cancer, has resulted to the identification of a large number of families with mutations in
Germline mutations in the BRCA2 gene have been shown to be associated with familial female and male breast cancer. Mutations occur throughout the entire coding region of the gene, and there is considerable ethnic and geographical diversity in the deleterious mutations detected in different populatio