Prevalence of Thyroid Cancer in Familial Adenomatous Polyposis Syndrome and the Role of Screening Ultrasound Examinations
✍ Scribed by Herraiz, Maite; Barbesino, Giuseppe; Faquin, William; Chan–Smutko, Gayun; Patel, Devanshi; Shannon, Kristen M.; Daniels, Gilbert H.; Chung, Daniel C.
- Book ID
- 122947987
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 530 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1542-3565
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Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T
## Abstract Within 36 months of its formation the Northern Region Polyposis Registry had increased the number of identified gene carriers of familial adenomatous polyposis from 56 to 65 in a population of 3·1 million and had achieved a 15-fold increase in the number of at-risk relatives being regul