## Abstract Our current understanding of breast cancer susceptibility involves mutations in the 2 major genes __BRCA1__ and __BRCA2__, found in about 25% of high‐risk families, as well as few other low penetrance genes such as __ATM__ and __CHEK2__. Approximately two‐thirds of the multiple cases fa
✦ LIBER ✦
Prevalence of the variant allele rs61764370 T>G in the 3′UTR ofKRASamong DutchBRCA1,BRCA2and non-BRCA1/BRCA2breast cancer families
✍ Scribed by Antoinette Hollestelle; Cory Pelletier; Maartje Hooning; Ellen Crepin; Mieke Schutte; Maxime Look; J. Margriet Collee; Anja Nieuwlaat; Lambert C. J. Dorssers; Caroline Seynaeve; Yurii S. Aulchenko; John W. M. Martens; Ans M. W. van den Ouweland; Joanne B. Weidhaas
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 203 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0167-6806
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Although in vitro splicing assays can provide useful information about the clinical interpretation of sequence variants in high-risk cancer genes such as BRCA1 and BRCA2, results can sometimes be difficult to interpret. The BRCA1 c.135-1G>T (IVS3-1G>T) variant has been shown to give rise to an in-fr