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Prevalence of mutations and determinants of genotypic resistance to etravirine (TMC125) in a large Italian resistance database (ARCA)

✍ Scribed by P Di Vincenzo; S Rusconi; F Adorni; P Vitiello; F Maggiolo; D Francisci; A Di Biagio; L Monno; A Antinori; E Boeri; G Punzi; C-F Perno; A Callegaro; B Bruzzone; M Zazzi; on behalf of the Antiretroviral Resistance Cohort Analysis (ARCA) Collaborative Group

Book ID
111063715
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
104 KB
Volume
11
Category
Article
ISSN
1464-2662

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## Abstract Multiple nucleoside resistance involves specific genetic changes in the HIV‐1 reverse transcriptase gene, such as Q151M mutation and an insertion of two serine aminoacids at RT codon 69. Among 432 patients failing antiretroviral therapy, five (1.15%) harboured viruses with Q151M mutatio