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Prevalence of genital HPV infections in a regularly screened population in the netherlands in relation to cervical cytology

✍ Scribed by Willem J. G. Melchers; Paul Herbrink; Wim G. V. Quint; Jan M. M. Walboomers; Chris J. L. M. Meijer; Jan Lindeman

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
438 KB
Volume
25
Category
Article
ISSN
0146-6615

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✦ Synopsis

To determine the prevalence of human papilloma virus (HPV) genotypes in relation to cervical cytology, 1,290 cervical samples from a regularly screened population of 3&55-year-old women were investigated. Gynaecological specimens, obtained from the cervix, were cytologically classified and screened for the presence of HPVs 6/11 and 16/ 18 using dot-spot DNA hybridisation. Of the cervical samples containing unequivocally normal cells, 21 of I ,27 1 ( I .6%) were found positive for HPV, and of the cervical samples containing cells with mild dysplasia, 6 of 14 (43%) were found positive for HPV. All five samples containing cells consistent with severe dysplasia or carcinoma in situ were found positive for HPV. Approximately 50% of the HPVpositive samples contained HPV 16 and/or HPV 18 DNA.

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