Prevalence of BRCA Mutations and Founder Effect in High-Risk Hispanic Families
β Scribed by Weitzel, J. N.
- Book ID
- 123621401
- Publisher
- American Association for Cancer Research
- Year
- 2005
- Tongue
- English
- Weight
- 157 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1055-9965
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## Abstract Three mutations in __BRCA1__ (5382insC, C61G and 4153delA) are common in Poland and account for the majority of mutations identified to date in Polish breast and breastβovarian cancer families. It is not known, however, to what extent these 3 founder mutations account for all of the BRC
We have investigated the impact of BRACA1 and BRACA2 mutations that were frequently identified among Hungarian high-risk breast-ovarian cancer families (Ramus et al., 1997b, AJHG), on the development of breast and ovarian cancer in the general Hungarian population. The prevalence of 3 BRCA1 mutation