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Prevalence and partial sequence analysis of human T cell lymphotropic virus type I in China

✍ Scribed by Youchun Wang; Xiouhua Li; Aijing Song; Chuntao Zhang; Ying Chen; Changrong Chen; Yisheng Lin; Liping Shun; Luilan Li; Yanchun Liu; Jian Yang; Bowei Yang; Qiouping Tang; Tim J. Harrison

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
78 KB
Volume
76
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

A total of 145,293 serum samples were collected from volunteer blood donors in 13 provinces of China and tested for anti‐HTLV antibody using an ELISA licensed in China. Thirty were positive for anti‐HTLV by ELISA and 19 of those 30 samples were confirmed positive using a supplemental immunoblot assay. Anti‐HTLV‐I was detected only in samples from Fujian province (a Southern province) where the positivity rate was approximately 0.05%. The region encoding gp46 from 5 of the 19 antibody positive samples was amplified and sequenced. Sequence analysis indicated that these isolates belong to HTLV‐I genotype A. These data suggest that HTLV‐I is not endemic throughout China and the virus may be restricted to a particular region. J. Med. Virol. 76:613–618, 2005. © 2005 Wiley‐Liss, Inc.

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