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Prevalence and functional consequence of PHOX2B mutations in neuroblastoma

✍ Scribed by Raabe, E H; Laudenslager, M; Winter, C; Wasserman, N; Cole, K; LaQuaglia, M; Maris, D J; Mosse, Y P; Maris, J M

Book ID
110072649
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
305 KB
Volume
27
Category
Article
ISSN
0950-9232

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Homozygosity for a dominant allele is relatively rare and preferentially observed in communities with high inbreeding. According to the definition of true dominance, similar phenotypes should be observed in patients heterozygous and homozygous for a dominant mutation. However, the homozygous phenoty