Pretreatment with eicosapentaenoic acid prevented hypoxia/reoxygenation-induced abnormality in endothelial gap junctional intercellular communication through inhibiting the tyrosine kinase activity

Involvement of tyrosine kinase in the hy

Involvement of tyrosine kinase in the hypoxia/reoxygenation-induced gap junctional intercellular communication abnormality in cultured human umbilical vein endothelial cells

✍ You-Wei Zhang; Ikuo Morita; Masamichi Nishida; Sei-Itsu Murota 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 277 KB 👁 2 views

Vascular endothelial cells (EC), communicating with one another across gap junctions, are usually made dysfunctional by hypoxia and reoxygenation (H/R); however, very limited information exists regarding the effects of H/R on the endothelial gap junctions. We investigated whether H/R interferes with