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Pretreatment nutritional status and locoregional failure of patients with head and neck cancer undergoing definitive concurrent chemoradiation therapy

✍ Scribed by Mary E. Platek; Mary E. Reid; Gregory E. Wilding; Wainwright Jaggernauth; Nestor R. Rigual; Wesley L. Hicks Jr; Saurin R. Popat; Graham W. Warren; Maureen Sullivan; Wade L. Thorstad; Mohamed K. Khan; Thom R. Loree; Anurag K. Singh

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 104 KB
Volume: 33
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21640

No coin nor oath required. For personal study only.

✦ Synopsis

Background. This study was carried out to determine if markers of nutritional status predict for locoregional failure following intensity-modulated radiation therapy (IMRT) with concurrent chemoradiotherapy (CCRT) for squamous cell carcinoma of the head and neck (SCCHN).

Methods. We performed a retrospective chart review of 78 patients with SCCHN who received definitive CCRT. We compared patient factors, tumor characteristics, and nutritional status indicators between patients with and without locoregional failure.

Results. Fifteen of 78 patients (19%) experienced locoregional failure. Median follow-up for live patients was 38 months. On univariate analysis, pretreatment percentage of ideal body weight (%IBW) (p < .01), pretreatment hemoglobin (p ¼ .04), and treatment duration (p < .01) were significant predictors of failure. On multivariate analysis, pretreatment %IBW (p ¼ .04) and treatment time (p < .01) remained statistically significant.

Conclusions. Although treatment time is an accepted risk factor for failure, differences in outcome for patients with head and neck cancer undergoing definitive CCRT based on pretreatment %IBW should be examined further. V

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