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Pretransplant emergence of lamivudine mutants does not enhance the risk of HBV reactivation

✍ Scribed by Raffaella Romeo; Lucio Caccamo; Giorgio Rossi; Floriana Facchetti; Luigi Rainiero Fassati; Massimo Colombo


Book ID
118565599
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
209 KB
Volume
36
Category
Article
ISSN
0168-8278

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Lamivudine (LAM) is a nucleoside analogue widely used for the treatment of chronic hepatitis B virus (HBV) infection. Emergence of resistant strains with amino acid substitutions in the tyrosine-methionine-aspartate-aspartate (YMDD) motif of reverse transcriptase is a serious problem in patients on