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Pretranslational control of Menkes disease gene expression

✍ Scribed by Edward D. Harris; Manchi C.M. Reddy; Sudeep Majumdar; Mariela Cantera

Book ID: 110398547
Publisher: Springer Netherlands
Year: 2003
Tongue: English
Weight: 175 KB
Volume: 16
Category: Article
ISSN: 1572-8773
DOI: 10.1023/a:1020706315825

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## Abstract Menkes disease is testament to a copper (Cu)‐ATPase (ATP7A) playing a dominant role in the absorption and homeostasis of Cu. Significantly, the proximal promoter region of the Menkes disease gene (__MNK__) has __cis__‐active elements that relate to binding sites for transcription factor