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Presynaptic low- and high-affinity kainate receptors in nociceptive spinal afferents

โœ Scribed by Simona Lucifora; Helen H. Willcockson; Chun-Rong Lu; Melanie Darstein; Kris D. Phend; Juli G. Valtschanoff; Aldo Rustioni


Book ID
116817790
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
446 KB
Volume
120
Category
Article
ISSN
0304-3959

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Overstimulation of ionotropic glutamate receptors leads to excitotoxic neuronal death, which has been implicated in the neurodegeneration of neurological diseases. The present study examined the role of putative low-affinity kainate receptor subtype (GluR5-7) agonists in excitotoxicity in cultured m