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Presynaptic effects of sodium bisulfite at the frog neuromuscular junction

✍ Scribed by Antoinette Steinacker

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
373 KB
Volume
7
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

Both spontaneous and evoked transmitter release from the frog neuromuscular junction can be modified by application of sodium bisulfite, a reagent specific for disulfide bonds. An increase in miniature endplate frequency is produced that is not dependent on external calcium, sodium, or presynaptic terminal depolarization. The increased release can be halted by application of the sulfhydryl oxidizing agent DTNB. The response of bisulfite can be prevented by prior treatment of the endplate with acetylcholine or an anticholinesterase. It is concluded that bisulfite produces its effects by acting on a protein in the presynaptic membrane that is involved in regulation of transmitter release.

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