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Presynaptic cross-talk of β-adrenoreceptor and 5-hydroxytryptamine receptor signalling in the modulation of glutamate release from cerebrocortical nerve terminals

✍ Scribed by Su-Jane Wang; Victoria Coutinho; Talvinder S Sihra


Book ID
110007605
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
219 KB
Volume
137
Category
Article
ISSN
0007-1188

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## Abstract Presynaptic 5‐HT~2A~ receptor modulation of glutamate release from rat cerebrocortical nerve terminals (synaptosomes) was investigated by using the 5‐HT~2A/2C~ receptor agonist (±)‐1‐[2,5‐dimethoxy‐4‐iodophenyl]‐2‐aminopropane (DOI). DOI potently inhibited 4‐aminopyridine (4AP)‐evoked g