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Presymptomatic screening for multiple endocrine neoplasia type 2A with linked DNA markers

✍ Scribed by Ponder, B.A.J.; Easton, D.F.; Nakamura, Y.; Mathew, C.G.P.


Book ID
122866849
Publisher
The Lancet
Year
1991
Tongue
English
Weight
682 KB
Volume
337
Category
Article
ISSN
0140-6736

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Medullary thyroid carcinoma occurs sporadically or as a part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. The MEN 2 gene has been identified as the RET proto-oncogene on chromosome 10. In MEN 2A, RET mutations are detectable in one of five cysteine codons within exons