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Presymptomatic DNA testing and prophylactic surgery in families with a BRCA1 or BRCA2 mutation

✍ Scribed by EJ Meijers-Heijboer; LC Verhoog; CTM Brekelmans; C Seynaeve; MMA Tilanus-Linthorst; A Wagner; L Dukel; P Devilee; AMW van den Ouweland; AN van Geel; JGM Klijn

Book ID: 117275598
Publisher: The Lancet
Year: 2000
Tongue: English
Weight: 98 KB
Volume: 355
Category: Article
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(00)02347-3

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## Abstract ## BACKGROUND. Prophylactic salpingo‐oophorectomy (SO), which is recommended in __BRCA1/2__ mutation carriers, still needs to be reappraised. ## METHODS. In all, 89 __BRCA1/BRCA2__ mutation carriers underwent SO between 1994–2004. Past medical and familial history, SO, results and su

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Prophylactic Salpingo-Oophorectomy in a Series of 89 Women Carrying a BRCA1 or a BRCA2 Mutation I read with great interest the article published in Cancer by Laki et al. 1 and strongly support that prophylactic salpingo-oophorectomy (SO) is an important option for BRCA1/2 mutation carriers, as asymp